Every year, poverty related diseases affect millions of people in the developing world. Yet, in the absence of clear profit potential, pharmaceutical companies are reluctant to invest in the development of treatments to fight these diseases. In response to this market failure, in the mid-1990s Product Development Partnerships (PDPs) emerged. PDPs use private sector approaches to tackle R&D challenges and target one or more poverty related diseases. In 2010 the Dutch Ministry of Foreign Affairs awarded €69.6m to seven PDPs for a period of four years (2011-2014): Aeras, DNDi, FIND, IAVI, IPM, Sabin and POW PDP. Collectively, these PDPs focus on improving the prevention, diagnosis and treatment of HIV/AIDS, tuberculosis and neglected tropical diseases (NTDs).
The Technopolis Group conducted an independent external review of this fund. With Dutch support, the PDPs have successfully progressed a number of promising drug and vaccine candidates through their R&D pipelines. Several of these are currently in clinical trials. Other products have reached or are about to reach the market. Additionally, the PDPs have stimulated research capacity development in developing countries. Many of the PDPs have successfully leveraged Dutch support to secure additional funding from other donors. Conversely, although not an explicit grant requirement, many Dutch universities, companies and NGOs have been vital partners in the PDP activities and have benefited from the funding. However, since many of the products are still under development, a final conclusion on the fulfilment of the PDP Fund objectives is not feasible.
The Technopolis Group advised the ministry of what factors should be taken into account in making a decision on possible continuation of the PDP Fund. The review contributed to a positive parliamentary advice from the minister on prolongation of the Dutch support to the PDPs.
Evidence on mechanisms and tools for use of health information for decision-making
The World Health Assembly in 2005 urged Member States to establish or strengthen knowledge transfer mechanisms to support evidence-informed health policies and health care delivery. The European Health Information Initiative was set up to strengthen the use of evidence, information and research for policy-making in the WHO European Region. While good-quality health information is a key component for…View report
The impact of collaboration: the value of UK medical research to EU science and health
The UK has a strong medical research community; the country’s withdrawal from the European Union (EU) can therefore be expected to have implications not only for the UK, but also for EU science and health. To better understand the UK’s contribution to medical research and patient health in the EU, a new study was commissioned…View report
Mid-term evaluation of the second Programme for Global Health and Vaccination Research (GLOBVAC2)
Technopolis recently completed its evaluation of the Global Health and Vaccination (GLOBVAC) research programme for the Research Council of Norway. Each year, the GLOBVAC research programme awards approximately €13 million in funding to research seeking to improve health for poor people in low and lower-middle income countries. The largest contributor is the Norwegian Agency for Development…View report